Cardiology in Tennessee

Daxor Corporation is a medical device company founded in 1970 and headquartered in Oak Ridge, Tennessee, specializing in blood volume measurement technology. The company's flagship product, the BVA-100 Blood Volume Analyzer, is an FDA-cleared diagnostic system that uses indicator dilution technique with I-131 Human Serum Albumin to provide precise quantification of total blood volume, plasma volume, and red cell mass in adult patients. The BVA-100 calculates normalized hematocrit and albumin transudation rate, enabling clinicians to detect hidden fluid imbalances that indirect measures miss. Daxor also supplies Volumex diagnostic kits, the radiopharmaceutical component required for blood volume analysis procedures. The technology is designed for hospital laboratory settings and clinical departments requiring critical fluid management decisions, including heart failure, critical care, sepsis, ARDS, syncope, and surgical blood loss assessment. The system is reimbursed by both public and private payers for inpatient and outpatient use, with demonstrated clinical outcomes in reducing mortality and hospital readmissions.

ProNova Solutions is a US-based medical device manufacturer and subsidiary of Provision Healthcare, LLC, specializing in advanced proton therapy beam delivery systems for cancer treatment. The company was founded by leaders who revolutionized cancer diagnostics through CT-PET integration and now applies that expertise to proton therapy innovation. ProNova's flagship product is the SC360 Proton Therapy System, the world's first and only 360° superconducting compact proton therapy system. This advanced system features a patented compact gantry design that creates a larger rectangular treatment room footprint while maintaining low energy consumption and construction costs. The SC360 supports sophisticated treatment modalities including SBRT (Stereotactic Body Radiation Therapy), with future capabilities for Arc and FLASH radiation therapy. Beyond clinical applications, ProNova operates a dedicated Radiation-Effects Program providing a specialized proton beam testing facility for semiconductor manufacturers, space industry, and aviation applications to assess mission-critical component reliability. The company is led by President and CEO Dr. Moataz Karmalawy and maintains a world-class technical operations team committed to advancing cancer treatment accessibility and improving clinical workflows through precision engineering and patient-centered innovation.

Sanders Medical Products Inc manufactures calibration sources and quality control solutions for Positron Emission Tomography (PET) and nuclear medicine imaging equipment. Since 1994, the company has specialized in PET sources approved by all major scanner manufacturers including Siemens, GE Healthcare, Philips, Concorde, Hamamatsu, Positron, and Shimadzu. Sanders Medical provides proprietary calibration sources designed to ensure scanner consistency and imaging quality, along with comprehensive services for PET facility maintenance and scanner normalization. The company offers lifetime warranty on sources and maintains a dedicated focus on medical imaging calibration and quality assurance.

CircumFix Solutions manufactures the VariTrax Sternal CircumFixator System, a rigid sternal closure device for cardiothoracic surgery. The system provides innovative sternal stabilization following median sternotomy procedures. The VariTrax device is fabricated entirely from PEEK (VESTAKEEP® polymer), a biocompatible, radiolucent material that offers 3D stability and load distribution across the anterior table of the sternum. The system combines a deformable anatomically conforming plate with PEEK compression bands (cerclage) in a unibody construction, enabling surgeons to splint the entire sternum while distributing closure forces more broadly than traditional wire cerclage methods. The product line includes six sized sternal circumfixator sets (ranging from 130mm to 186mm), a template kit for intraoperative sizing, an instrument kit, and individual PEEK bands with curved blunt needles. All components are supplied as sterile kits. The VariTrax system has received FDA clearance and is designed for quick and easy application with simple removal. CircumFix targets cardiothoracic surgical centers and hospitals performing high-volume median sternotomy procedures (approximately 700,000 annually in the USA). The company provides comprehensive Instructions for Use (IFU) documentation, clinical support materials, and educational resources including video demonstration of surgical technique. Manufacturing and regulatory compliance align with medical device standards for surgical implants and instruments used in cardiac surgery.

Innovative Oncology Solutions (IOS) is a medical device distributor and supplier founded in 2016 by oncology and medical device industry veterans with over 40 years of combined experience. The company specializes in radiation oncology positioning and immobilization products, including thermoplastic masks, fiducial markers, vacuum cushions, and specialized positioning hardware for cancer treatment planning and delivery. IOS sources high-quality, competitively priced products for oncology clinics and hospitals, subjecting all offerings to rigorous evaluation to ensure clinical efficacy and reliability. The company operates as an employee-owned entity with a commitment to rapid distribution and customer support.