Decision Support in Minnesota

NightWare is a prescription digital therapeutic system designed to reduce sleep disturbance associated with Nightmare Disorder and nightmares related to post-traumatic stress disorder (PTSD). The company's flagship product is the first and only FDA-cleared Class II digital therapeutic specifically indicated for nightmare-related sleep disturbance in adults 22 and older. The system leverages Apple products and proprietary algorithms to deliver adaptive interventions that respond to individual patient sleep patterns without waking patients. NightWare received FDA Breakthrough Device designation in 2020, reflecting unmet clinical need and preliminary evidence of substantial improvement on clinically significant endpoints. Safety and efficacy are supported by ongoing randomized, double-blind, placebo-controlled clinical trials, including a pivotal study at Walter Reed. The therapy requires no drug interactions, integrates with existing PTSD and nightmare treatments, and demonstrates clinically meaningful improvement within two weeks of initiation. The company serves both healthcare professionals and patients directly, providing clinical evidence, educational resources, and professional support materials to facilitate adoption across mental health, sleep medicine, and trauma care settings.

Ambient Clinical Analytics is a digital health and clinical decision support software company providing FDA Class II and CE Mark-approved solutions for acute care hospitals and health systems. The company specializes in real-time clinical analytics platforms that integrate with existing EHR workflows to reduce alert fatigue, prevent errors, and improve patient outcomes. Primary product lines include Sepsis DART™, an automated sepsis detection and treatment bundle monitoring system; AWARE Clinical Control Tower™, a centralized tele-ICU and clinical command center platform for remote monitoring and collaboration; AWARE Patient Surveillance™ (AWARE Patient View™), providing telehealth and remote patient monitoring via proprietary Clinical Mesh Network™ technology; AWARE Certain™, a clinical intelligence platform for standardized patient evaluation and treatment; and YES Board™, a patient flow management system designed to reduce wait times and length of stay. All platforms leverage clinically vetted rules, indicative and predictive analytics, and smart notifications to guide clinical teams through complex care processes. The company's solutions are designed for deployment across entire health systems and support both centralized and decentralized care models. Ambient markets to hospital administrators, ICU directors, infectious disease specialists, and nursing leadership. Products are commercially deployed in acute care settings and demonstrate compliance with CMS Sepsis-1 reporting requirements. The company emphasizes scientific validation and cost reduction through error prevention and improved care timeliness.

Microbiologics is a leading provider of biological reference materials, quality controls, and contract research organization (CRO) services for microbiology, molecular diagnostics, and virology. Founded over 50 years ago and headquartered in Saint Cloud, Minnesota, the company serves healthcare and life science laboratories, diagnostic manufacturers, and biopharmaceutical companies globally. In microbiology, Microbiologics offers the industry's largest collection of reference strains in ready-to-use formats including KWIK-STIK™, EZ-Accu Shot™, Epower™, and LYFO DISK™ products for quality control of growth promotion testing, enumeration methods, and antimicrobial effectiveness testing. The company provides custom microbiology services including environmental isolate controls, antimicrobial assays, microbiome testing, and proficiency testing solutions. In molecular diagnostics, Microbiologics manufactures external third-party IVD quality controls and reference standards under the Helix Elite™ brand for infectious disease diagnostics (respiratory, STI/women's health, gastrointestinal, healthcare-associated infections) and oncology (gDNA, cfDNA/ctDNA, FFPE). Virology capabilities include BSL-2 and BSL-3 contract research laboratories offering custom and off-the-shelf viral stocks, recombinant virus production, adventitious virus panels, viral assay development, and antiviral drug and vaccine testing services. The company maintains ISO 17025 accredited facilities and provides certified reference materials (CRM) for regulated laboratory environments. Microbiologics serves IVD manufacturers, pharmaceutical companies, clinical diagnostic laboratories, and research institutions across North America, Europe, and globally.