Neurology in Pennsylvania

InfraScan, Inc. is a medical device manufacturer specializing in portable brain imaging for rapid detection of intracranial bleeding and traumatic brain injury. The company develops and commercializes the Infrascanner®, a portable screening device using Near-Infrared (NIR) spectroscopy technology to identify patients with intracranial hematomas who require immediate CT imaging and neurosurgical intervention. The Infrascanner 2500 enables non-invasive, bedside assessment of head trauma patients in emergency departments, intensive care units, military field hospitals, ambulance services, and remote locations without requiring transport to imaging facilities. Over 200 devices have been deployed to all USMC Battalion Aid Stations as part of standard trauma kits. The technology was invented by Dr. Britton Chance (University of Pennsylvania) and Dr. Claudia Robertson (Baylor College of Medicine), validated in clinical studies of 305 patients at Baylor College of Medicine. FDA-cleared and CE-marked, the Infrascanner has been studied at distinguished teaching hospitals and specialty pediatric facilities throughout the U.S. and has demonstrated clinical utility in both adult and pediatric populations internationally. The device addresses a critical gap in point-of-care neuroimaging, particularly valuable in military trauma settings, remote locations, and resource-limited environments where immediate CT access is unavailable. InfraScan holds regulatory clearances enabling use across emergency medicine, neurocritical care, military medicine, and sports medicine applications.

Actuated Medical develops patented platform technologies for minimally-invasive brain access, implant insertion, and therapeutic delivery. The company specializes in two primary product lines: the NeuralGlider Inserter, which uses micro-oscillation technology to insert brain implants with improved precision and reduced tissue trauma, enhancing implant performance and longevity; and the NeuralGlider Injector, which enables targeted drug delivery deep into the brain using finer, less-invasive needles to minimize tissue damage and medication loss. These technologies serve partners developing deep brain stimulation (DBS), neurological implants, and intracranial drug therapies for conditions including Parkinson's disease, epilepsy, treatment-resistant neurological disorders, brain cancer, AAV gene therapy, and addiction treatments. Actuated Medical positions itself as a foundational platform provider that collaborates with leading innovators in neurotechnology and brain therapeutics. The company has demonstrated significant scientific traction through peer-reviewed publications and preclinical validation studies. Their technology addresses critical clinical needs in neurological treatment where precise brain access and minimal tissue trauma directly impact patient outcomes and long-term implant efficacy.

TransducerWorks, founded in 2007 and part of the Vermon Group since 2018, is a U.S.-based manufacturer of custom ultrasound transducers, arrays, and probes for medical and industrial applications. The company employs 100+ engineers and manufacturing experts in Pennsylvania and delivers high-performance solutions for OEMs in diagnostics, point-of-care, interventional, veterinary, and innovation-driven medical sectors. TransducerWorks specializes in medical diagnostic probes for radiology, cardiovascular, and OB/GYN imaging, including portable and handheld (POCUS) systems for emergency and ICU use. The company also develops therapeutic ultrasound solutions for neurostimulation, neuromodulation, and targeted drug delivery, spanning focused (HIFU, LIFU) and unfocused (LIPUS) applications at frequencies above 500 kHz. Veterinary ultrasound offerings cover all species with rugged, cost-effective designs compatible with portable or cart systems. TransducerWorks operates under ISO 13485 certification with FDA compliance, RoHS and REACH adherence, ensuring precision, traceability, and regulatory alignment for medical device manufacturers and research institutions.

Computational Diagnostics, Inc. (CDI) is a manufacturer of clinical neurophysiology systems and provider of intraoperative neurophysiological monitoring (IOM/IONM) services. Founded in 1988, CDI develops and operates multi-modality neurophysiologic monitoring equipment designed to protect neural structures during surgical procedures. The company's flagship NeuroNet® platform enables real-time neurophysiological data acquisition and remote interpretation by attending neurophysiologists, allowing surgeons to monitor nervous system integrity during complex procedures. CDI offers turnkey IOM services with nationally certified neurotechnologists and neurophysiologists collaborating to deliver immediate clinical feedback. The company also develops telemedicine and home-use neurophysiology systems, supported by research funding from the Army's Telemedicine and Advanced Technology Research Center and the National Institute of Neurological Diseases and Stroke. CDI's technology has received recognition including Computer World/Smithsonian awards.

Ultraflex Systems manufactures individualized orthopedic and neurological bracing solutions for adults and pediatrics. The company specializes in FDA Class I custom-molded braces designed to control multi-planar motion and stretch multiple joints simultaneously. Ultraflex's proprietary Low Load Prolonged Stress (LLPS) and Adjustable Dynamic Response™ (ADR) technologies are engineered to improve dynamic and static range of motion, enhance gait function, and support muscle flexibility. Clinical applications include cerebral palsy, cerebrovascular accident, traumatic brain injury, muscular dystrophy, multiple sclerosis, incomplete spinal cord injury, and other central nervous system disorders. All braces require physician prescription and are fitted by certified professionals. The company operates a 9,000 sq ft custom fabrication facility and distributes globally through qualified partners in Europe, Canada, Australia, and Japan. Ultraflex is committed to evidence-based practice, clinical education, and ongoing comparative effectiveness research.

Inteprod LLC is an ISO 13485:2016-certified contract manufacturer of medical devices and life science diagnostic products. The company serves medical device OEMs and emerging innovators throughout the product lifecycle, from concept through manufacturing scale-up and commercialization. Inteprod specializes in electromechanical device manufacturing with demonstrated expertise in design for manufacturing, process optimization, and quality assurance. The company is FDA-registered and complies with 21 CFR 820 regulatory requirements, UL, IEC, and CE standards. Notable past projects include manufacturing of a TBI (traumatic brain injury) handheld cranial scanning device. Inteprod has a documented track record of zero audit findings and maintains relationships with major medical device manufacturers including BD, C.R. Bard, and Olympus. The company emphasizes proactive problem-solving, cost reduction, accelerated time-to-market, and reliable delivery against agreed milestones. Manufacturing capabilities encompass electromechanical assembly, device integration, and full-scale production support. Inteprod operates as a partner-focused contract manufacturer rather than an OEM of branded finished products.

MindTrace is a Pittsburgh-based AI/ML software platform (Carnegie Mellon University spinoff, founded 2020) designed to support neurosurgical planning and intraoperative decision-making. The platform integrates multiple data sources to enable clinicians to predict cognitive outcomes before, during, and after brain surgery. MindTrace provides structured neurocognitive assessment workflows—measuring language, memory, attention, and other critical functions—allowing surgical teams to iterate on resection strategies while evaluating trade-offs between lesion removal and preservation of healthy brain tissue. The system integrates into clinical, operating room, and epilepsy monitoring workflows, supporting inpatient, perioperative, intraoperative, and telehealth settings. Used across U.S. medical centers under IRB oversight, MindTrace bridges clinical neurocognitive assessment with translational research data collection, enabling reproducible multi-site studies without custom infrastructure. The platform serves neurosurgeons, hospitals, researchers, and patients seeking evidence-based preoperative surgical planning and quantitative projections of postoperative function and quality of life.

Reliefband® is an FDA-cleared, Class II neuromodulation wearable device that treats nausea and vomiting through patented median nerve stimulation. Originally developed for hospital use, the device applies gentle electrical pulses to the underside of the wrist, sending signals through the nervous system to the brain's nausea control center, effectively reducing symptoms without drugs or side effects. Clinically proven and hospital-validated for motion sickness, migraines, anxiety, morning sickness, chemotherapy-induced nausea, post-operative nausea, and hangovers. Available in multiple models (Classic, Flex, Sport, Premier, Premier+) with varying battery life and features. Hypoallergenic gel application required for optimal efficacy. FSA/HSA eligible, non-drowsy, drug-free alternative to antiemetic medications with no contraindications for pregnant women or medication interactions.

ANT Neuro is a global neurotechnology company specializing in EEG (electroencephalography) systems, neuronavigation solutions, and neurofeedback platforms for clinical diagnostics and neuroscience research. The company manufactures and distributes high-density EEG amplifiers (eego™ product line), EEG caps and electrodes, and the visor2™ navigated transcranial magnetic stimulation (TMS) system, which is FDA 510(k)-cleared. Their solutions serve neurologists, neuroscientists, psychiatrists, and research institutions worldwide. ANT Neuro operates through regional distribution centers in the Netherlands, Germany, UK, Asia-Pacific, North America, and Australia, with local sales and application support teams. The company maintains CE and MDR compliance for medical devices and hosts the international ANT Neuromeeting conference annually, underscoring their commitment to advancing clinical and research neurotechnology. Products address functional diagnostics including EEG/EMG applications in sleep studies, epilepsy monitoring, and brain-computer interface research.