Surgical Navigation Systems in Pennsylvania

Waypoint Orthopedics is a spine surgery medical device company founded by Dr. Stephen Banco and backed by Runway Healthcare, LP. The company specializes in vertebral fixation systems designed to reduce radiation exposure and enhance surgical efficiency in open and minimally invasive spine procedures. Waypoint's primary product is the GPS (Guided Pedicle System), an FDA-approved surgical navigation system that provides real-time intraoperative guidance for pedicle screw placement. The system addresses a critical occupational health concern: spine surgeons routinely exceed their lifetime radiation exposure limits within the first decade of practice, experiencing up to 12 times higher radiation exposure than other fluoroscopically-assisted surgical specialties. The GPS system enables more confident pedicle screw positioning while substantially reducing radiation exposure to surgeons, operating room staff, and patients. The company's regulatory credentials include FDA approval for use in both open and minimally invasive spine (MIS) surgery. Leadership includes seasoned medtech executives, with clinical guidance from a surgeon advisory board comprising experienced spine surgeons. Waypoint targets hospital and ambulatory surgical center OR environments performing routine spinal fusion and stabilization procedures. The company positions its technology at a large addressable market—approximately 1.62 million spine surgeries annually in the United States—where pedicle screw fixation is a standard technique.

Actuated Medical develops patented platform technologies for minimally-invasive brain access, implant insertion, and therapeutic delivery. The company specializes in two primary product lines: the NeuralGlider Inserter, which uses micro-oscillation technology to insert brain implants with improved precision and reduced tissue trauma, enhancing implant performance and longevity; and the NeuralGlider Injector, which enables targeted drug delivery deep into the brain using finer, less-invasive needles to minimize tissue damage and medication loss. These technologies serve partners developing deep brain stimulation (DBS), neurological implants, and intracranial drug therapies for conditions including Parkinson's disease, epilepsy, treatment-resistant neurological disorders, brain cancer, AAV gene therapy, and addiction treatments. Actuated Medical positions itself as a foundational platform provider that collaborates with leading innovators in neurotechnology and brain therapeutics. The company has demonstrated significant scientific traction through peer-reviewed publications and preclinical validation studies. Their technology addresses critical clinical needs in neurological treatment where precise brain access and minimal tissue trauma directly impact patient outcomes and long-term implant efficacy.

inTRAvent Medical Partners LP is a medical device company specializing in intra-operative imaging and neuro-navigation systems for neurosurgical procedures. The company develops portable ultrasound-based navigation technology enhanced with artificial intelligence and trajectory guidance to improve safety and efficacy in neurosurgery. Their flagship product, SOLOPASS®, combines 2D and 3D ultrasound imaging with AI-driven guidance to provide real-time procedural localization and navigation at the bedside. Designed for neurosurgeons performing minimally invasive procedures, the technology enables enhanced visualization of anatomical structures and catheter placement guidance. The company is focused on translating advanced imaging and navigation capabilities into practical, user-friendly solutions for intraoperative use.

Computational Diagnostics, Inc. (CDI) is a manufacturer of clinical neurophysiology systems and provider of intraoperative neurophysiological monitoring (IOM/IONM) services. Founded in 1988, CDI develops and operates multi-modality neurophysiologic monitoring equipment designed to protect neural structures during surgical procedures. The company's flagship NeuroNet® platform enables real-time neurophysiological data acquisition and remote interpretation by attending neurophysiologists, allowing surgeons to monitor nervous system integrity during complex procedures. CDI offers turnkey IOM services with nationally certified neurotechnologists and neurophysiologists collaborating to deliver immediate clinical feedback. The company also develops telemedicine and home-use neurophysiology systems, supported by research funding from the Army's Telemedicine and Advanced Technology Research Center and the National Institute of Neurological Diseases and Stroke. CDI's technology has received recognition including Computer World/Smithsonian awards.

MindTrace is a Pittsburgh-based AI/ML software platform (Carnegie Mellon University spinoff, founded 2020) designed to support neurosurgical planning and intraoperative decision-making. The platform integrates multiple data sources to enable clinicians to predict cognitive outcomes before, during, and after brain surgery. MindTrace provides structured neurocognitive assessment workflows—measuring language, memory, attention, and other critical functions—allowing surgical teams to iterate on resection strategies while evaluating trade-offs between lesion removal and preservation of healthy brain tissue. The system integrates into clinical, operating room, and epilepsy monitoring workflows, supporting inpatient, perioperative, intraoperative, and telehealth settings. Used across U.S. medical centers under IRB oversight, MindTrace bridges clinical neurocognitive assessment with translational research data collection, enabling reproducible multi-site studies without custom infrastructure. The platform serves neurosurgeons, hospitals, researchers, and patients seeking evidence-based preoperative surgical planning and quantitative projections of postoperative function and quality of life.