Advanced Cell Diagnostics

Advanced Cell Diagnostics (ACD), a Bio-Techne brand, specializes in molecular pathology and spatial biology solutions for research, drug development, and precision medicine. The company is renowned for its proprietary RNAscope® in situ hybridization (ISH) technology, which enables precise RNA biomarker analysis at single-molecule resolution within preserved tissue and cellular morphology. ACD's extensive product portfolio—including over 9,000 offerings—encompasses RNAscope™ assays (standard, multiplex fluorescent, and HiPlex versions), BaseScope™ assays for DNA and splice variant detection, miRNAscope™ for microRNA analysis, DNAscope™ for chromogenic DNA detection, and RNA-protein co-detection assays for spatial multiomics. The company also provides Professional Assay Services (PAS) for custom probe development and high-throughput biomarker analysis supporting applications in immuno-oncology, gene therapy, drug safety assessment, and patient-derived xenograft (PDX) characterization. With headquarters in Newark, CA, and global operations in the UK and China, ACD serves academic institutions, pharmaceutical companies, and contract research organizations worldwide.