Pleural Dynamics, Inc.

Pleural Dynamics is a Minneapolis-based medical device innovator specializing in minimally invasive solutions for chronic fluid collections within the body. The company's flagship product, ACES (Automatic Continuous Effusion Shunt), is an FDA-cleared implantable device designed to treat chronic recurrent pleural effusions—excess fluid accumulation between the lung and chest wall that causes severe dyspnea, cough, and reduced quality of life. ACES leverages the body's natural breathing motion to automatically and continuously transfer pleural fluid into the abdomen for reabsorption, eliminating the need for repeated drainage procedures, external catheters, or prolonged hospitalization. With a 1-day or less hospital stay, zero 30-day failure rate, and zero pleural infection rate in clinical trials, ACES offers superior clinical outcomes and cost-effectiveness compared to traditional pleurodesis and indwelling pleural catheter approaches. The device targets the approximately 660,000 new patients annually in the US and Europe with recurrent pleural effusions, representing a $1.5B annual market opportunity. Pleural Dynamics addresses a significant clinical unmet need by providing sustained symptom relief while reducing infection risk, caregiver burden, and overall healthcare costs.