RESPIRATORY RESEARCH, INC.

Respiratory Research, Inc. is a US-based manufacturer of RTube™, a validated, non-invasive exhaled breath condensate (EBC) collection platform widely adopted in clinical research and occupational health monitoring. The company specializes in breath biomarker sampling devices engineered for reproducible, contamination-free collection of respiratory samples from ambulatory and ventilated populations. RTube™ captures dissolved and aerosolized components of exhaled air, enabling analysis of biomarkers including DNA, RNA, microRNA, proteins, cytokines, nitrogen oxides, pH, hydrogen peroxide, volatile organic compounds (VOCs), and metabolites like 8-isoprostane. The product line includes three main variants: RTube (general EBC collection), RTubeVOC (end-tidal air/VOC capture), and RTubeVENT (in-line collector for ventilated patients). Manufacturing is performed in an ISO 8 cleanroom facility under ISO 13485 certification, with proprietary cleaning protocols to eliminate chemical and organic contaminants. The company reports over 230,000 collections worldwide and 400+ peer-reviewed publications supporting RTube use. RTube is marketed as scalable for decentralized clinical trials, academic research, population health studies, and industrial hygiene programs. The platform offers minimal operational burden—no cold chain, simplified training, and single-use sealed design avoiding sample transfer contamination. Starter kits are available for feasibility studies, with comprehensive support from protocol development through publication.