Twist Bioscience Corporation

Twist Bioscience Corporation is a US-based synthetic biology company specializing in DNA-based research tools and services. The company operates a proprietary semiconductor-based synthetic DNA manufacturing platform utilizing high-throughput silicon technology for miniaturized chemistry and cost-efficient DNA synthesis. Core product portfolio includes synthetic genes (clonal genes, gene fragments, gene pools, vectors), oligonucleotide pools (cloned and uncloned), next-generation sequencing (NGS) target enrichment solutions, library preparation kits (including TrueAmp Library Prep Kit and PCR-free WGS kits), variant libraries (combinatorial, site saturation, spread-out low diversity), and synthetic controls for infectious disease and liquid biopsy applications. The company also offers comprehensive antibody discovery and development services including in vitro phage display, in vivo discovery using Diversimab technology and humanized transgenic mice, antibody characterization (SPR, developability assessment, functional assays), and optimization services including AI/ML-driven affinity maturation and in silico humanization. Twist Service Lab provides outsourced sequencing services, and the company offers automation solutions and API-based procurement integration. Target markets include academic research, pharmaceutical drug discovery, cancer research, infectious disease research, agricultural biotechnology, and clinical diagnostics. The platform enables researchers to access customizable gene synthesis at varying scales, perform high-confidence genomic screening, and conduct precision variant detection across NGS workflows.