Cardiology in Ohio

Codonics, Inc. is a Cleveland-based medical technology innovator specializing in patient safety and medication management solutions. Founded in 1982, the company has deployed over 60,000 installations across more than 110 countries. The Safe Label System (SLS)—Codonics' flagship product—enhances medication safety through real-time barcode scanning and automated labeling at the point of care, reducing administration errors and ensuring TJC and ISMP compliance. SLS integrates seamlessly with anesthesia drug carts and pharmacy workflows across operating rooms, intensive care units, patient floors, and pharmacy departments. Additional offerings include the SLS-Wave (hands-free scanning), Safe Waste System (controlled substance tracking), WasteLog (waste verification), and SLS Administration Tool (formulary management). Recognized as a Top 100 Healthcare Technology Company of 2024 and awarded Medication Safety Technology Company of the Year 2025, Codonics delivers solutions that streamline clinical workflows, improve charge capture, ensure 340B compliance, and prevent medication errors in perioperative and procedural settings.

Estone Technology is a global ODM/OEM designer and manufacturer of rugged computing devices for medical, industrial, military, and mission-critical applications. With over 20 years of expertise, the company specializes in custom-built rugged tablet PCs, medical-grade tablets, industrial panel PCs, HMI systems, and embedded computing solutions. Medical product lines include the EN-150 (15.6" AI-enabled tablet for endoscopy, X-ray, and ultrasound image processing), MJ-80 (8" medical rugged tablet), and MD-100 (10.1" medical tablet). Industrial offerings encompass HMI control panels (HMI-70, HMI-1500) and panel PCs (PPC-4107) designed for cleanroom and automated manufacturing environments. Rugged product line includes the UR-100N (10.1" Windows tablet), MS-100A (10.1" Android tablet), and MJ-60 (6" handheld). The company provides full-stack ODM/OEM services: hardware design and PCB engineering, software development (MDM/RDM, application, OS/firmware), device management systems, and AI integration. Estone devices meet MIL-STD-810G/H (environmental durability), MIL-STD-461G (electromagnetic compatibility), and IP67/IP68 waterproofing standards. Additional technologies include RFID integration, CAC/smart card readers, and Ultra-Wideband (UWB) connectivity. Estone operates global offices in the US (Toledo, OH headquarters; Walnut, CA), Europe (Eindhoven, Netherlands), Japan, and China, serving healthcare, industrial automation, logistics, military, and smart agriculture sectors.

SPR Therapeutics is a Cleveland-based medical device company specializing in peripheral nerve stimulation (PNS) technology for non-opioid, non-surgical pain management. Founded in 2010, the company develops innovative neuromodulation solutions targeting chronic pain, acute pain, post-surgical pain, and post-traumatic pain. The company's flagship product, the SPR® SPRINT® Peripheral Nerve Stimulation System, is the only FDA-approved percutaneous PNS system designed for both chronic and acute indications. SPR Therapeutics' mission centers on providing drug-free alternatives to opioids and invasive surgical procedures, directly addressing the opioid crisis. The company has demonstrated strong clinical evidence with over 200 patents, Department of Defense and NIH funding support, and real-world efficacy showing pain relief in over 70% of patients with more than 50,000 implants performed. SPR continues to advance next-generation pain therapies while expanding market coverage and clinical adoption.

ViewRay Systems, Inc. is a medical device manufacturer specializing in MRI-guided radiation therapy (MR-gRT) systems for precision cancer treatment. The company's flagship product, MRIdian A3i, integrates diagnostic-quality MRI imaging with radiation delivery and proprietary software to enable real-time soft-tissue visualization, automated beam control, and adaptive dosing. This technology allows radiation oncology centers to reduce treatment volumes, minimize side effects, and improve patient outcomes across multiple cancer types including pancreatic, prostate, lung, liver, breast, and oligometastatic cancers. MRIdian A3i is compatible with existing radiation therapy vaults, facilitating institutional adoption. ViewRay Systems serves university hospitals, community hospitals, private practices, and specialized cancer centers worldwide, supporting program expansion in advanced precision oncology with peer-reviewed clinical evidence demonstrating reduced treatment toxicity and extended survival.

DEM Medical (PADCO Holding Company) is a turnkey product development and contract manufacturing firm specializing in FDA-compliant, ISO 13485:16-certified medical device manufacturing. Founded in 1993 and based in the USA, DEM provides end-to-end design, engineering, and manufacturing services for the medical device industry, with capabilities spanning printed circuit board assemblies (PCBA), custom cabling and connectors, injection molding, 3D printing and rapid prototyping, and tooling design. The company is vertically integrated—all design, engineering, and production occur in-house—enabling rapid prototyping (as little as 10 weeks from concept to prototype), transparent pricing, and rigorous quality assurance. DEM holds ITAR, ISO 9001:15, ISO 13485:16, IPC-620, FDA Class II, REACH, and RoHS certifications. The firm serves medical device OEMs, startups, and innovators requiring custom, low-to-high-volume production with dependable delivery schedules and compliance-ready solutions.

Smithers Medical Products manufactures Alpha Cradle®, a proprietary non-toxic foam repositioning and immobilization system designed exclusively for radiation oncology and cancer treatment. The company specializes in custom anatomical forms that securely position patients for daily treatment sessions, enabling precise tumor targeting with reduced collateral radiation exposure. Alpha Cradle products are CFC-free, environmentally recyclable, and designed for use across all treatment modalities. The foam is thermoplastic-compatible and can be customized on-site using standard tools. Smithers offers pre-measured kits for specific treatment setups and provides lifetime discounts to VA medical centers. With over 40 years of foam refinement, the company focuses on patient comfort, safety, and clinical outcomes in radiation therapy positioning.

Norwood Medical is a contract manufacturer and precision engineering partner specializing in medtech component and device manufacturing. Operating from a 700,000 square-foot manufacturing campus in Dayton, Ohio, the company serves leading surgical device manufacturers across cardiovascular, minimally invasive surgery (MIS), orthopedic, and robotic-assisted surgery (RAS) markets. Founded nearly a century ago, Norwood offers end-to-end capabilities spanning design for manufacturability (DFM), engineering, prototyping, tooling development, precision machining, metal injection molding (MIM), electro-chemical machining (ECM), automation, secondary processing, assembly, testing, and packaging. The company operates over 800 CNC machines (milling, turning, 5-axis, Swiss machining), automated robotic systems with vision and laser technology, and specialized electrochemical machining equipment. Norwood manufactures components at tight tolerances for complex surgical instruments and implantable devices, with in-house capabilities for metal injection molding feedstock mixing and insert molding. The firm maintains strong quality and on-time delivery metrics and serves as sole supplier to approximately 32% of its customer base. Quality certifications and regulatory compliance capabilities support OEM partners across FDA-regulated device categories.

Havel's, Inc. is a specialty medical supplies distributor founded in 1981, headquartered in Cincinnati, Ohio. The company is the exclusive North American distributor of Hakko® Medical needle devices, manufactured in Japan and recognized as the global benchmark for needle quality and safety. Havel's specializes in high-quality medical consumables including specialty procedure needles (anesthesia, regional blocks, radiology/biopsy), surgical blades, suture products for human and veterinary use, and surgical handles. Their product portfolio features proprietary technologies such as echogenic ultrasound needles with corner cube reflectors (CCR®) and Micro Laser Etching (MLE™) for enhanced visibility during ultrasound-guided procedures. The company serves office-based surgeons, anesthesiologists, and interventional specialists with sterile, stainless steel instruments and carbon steel scalpel blades. Havel's is known for quality, competitive pricing, and exceptional customer service in the B2B medical device distribution sector.

CNMC Company is a specialized supplier of radiation physics and quality assurance equipment serving the medical radiation community. The company provides a comprehensive portfolio of dosimetry devices, ionization chambers, survey meters, brachytherapy accessories, phantoms, and calibration services. CNMC specializes in products for linear accelerator QA/QC, diagnostic radiology, brachytherapy localization, IMRT planning, and radiation protection. The product range includes electrometers, diode and MOSFET dosimeters, TLD dosimeters, ion chamber survey meters, personal dosimeters, various ionization chamber types, positioning and immobilization devices, and custom QA phantoms. The company also offers repair services and unparalleled customer support with custom product development capabilities.

Sirona Complete Care is a specialized distributor of medical imaging accessories for Nuclear Medicine, Nuclear Cardiology, PET/CT, and molecular imaging applications. The company supplies radioactive sources, imaging phantoms, patient positioning systems, radiation detection equipment, and nuclear medicine accessories to healthcare facilities and research institutions. Sirona's product portfolio includes PET sources, survey meters, gamma detection systems, patient support systems, table pads, and theranostics solutions. Known for deep industry expertise, rapid sourcing capabilities, and personalized customer service, Sirona serves as a trusted partner to nuclear medicine technologists, cardiologists, and imaging departments across North America, with particular strength in alternative sourcing and quick-access inventory management.

N8 Medical LLC is a clinical-stage medical device company specializing in antimicrobial coating technology based on ceragenins—a novel class of active compounds that mimic innate immune system antimicrobial peptides. The company's lead product, CeraShield, is an antimicrobial coating applied to indwelling medical devices and implants to prevent hospital-acquired infections (HAIs) and biofilm formation. The flagship device is the CeraShield Endotracheal Tube (ETT), designed to prevent Ventilator-Associated Pneumonia (VAP), the most common and costly HAI in ICU settings with estimated global treatment costs exceeding $10 billion annually. The FDA has designated CeraShield ETT as a "Breakthrough Device" and it is cleared for routine clinical use in Canada, Colombia, Brazil, and the UAE, with FDA approval anticipated. N8 Medical's pipeline includes additional CeraShield-coated devices: an antimicrobial absorbable pacemaker envelope for prevention of cardiac implantable electronic device (CIED) infections, and coated pedicle screws for orthopedic implant-associated infection prevention. The company is also developing CeraShield-coated hemodialysis catheters. N8 Medical operates as part of N8 Biosciences holding company and maintains a pharmaceutical subsidiary, Kinnear Pharmaceuticals, advancing therapeutic drug development using ceragenins for cystic fibrosis and other conditions. The company has received multiple NIH SBIR grants and maintains partnerships with government agencies including USAMRIID for biodefense applications.

Rayonex Biomedical GmbH is a German medical device manufacturer established in 1982, specializing in bioresonance therapy devices based on the treatment methodology of Bioresonance according to Paul Schmidt. The company manufactures Class I and IIa medical devices certified to DIN EN ISO 13485 and audited annually by TÜV Nord. Products include the Rayocomp PS 1000 polar 4.0 med. (high-end bioresonance device with ECG-based Rayoscan® diagnostic capability for biofeedback analysis) and the portable Rayocomp PS 10 med. for home use. The bioresonance approach is based on cellular stimulation to support organismal self-regulation; the company has recorded over 3,600 frequency spectra for human and veterinary applications. A double-blind, randomized, placebo-controlled clinical study demonstrated efficacy in treating chronic cervical spine syndrome pain. Beyond medical applications, Rayonex produces non-medical bioresonance devices for veterinary medicine, building biology, and wellness; biofield formers; and nutritional supplements containing minerals, trace elements, vitamins, and probiotic cultures. Manufacturing is CO2-neutral and utilizes high-precision robotics at the company's Lennestadt facility in Germany's Sauerland region. Products are distributed in 46 countries; over 10 million treatments are performed annually with Rayonex devices. The company also offers certified practitioner training courses in Bioresonance according to Paul Schmidt for healthcare professionals. While scientific studies support efficacy, bioresonance remains a complementary therapy not yet officially recognized by conventional medicine.