Clinical Software in North Carolina

Amann Girrbach AG is a global manufacturer of digital dental CAD/CAM systems, materials, and software for dental laboratories and chairside dental practices. The company offers an integrated Ceramill workflow ecosystem comprising milling equipment (CNC units), scanning systems, design and production software, and a comprehensive range of restorative materials including zirconia, metals, polymers, 3D resins, and casting materials. Primary product lines include Ceramill Motion Air, Ceramill Matron, Ceramill Motion 3, and Ceramill Matik milling machines; Ceramill Map 600+ optical scanner; Ceramill Mind design software; and the Zolid zirconia family (Lunaris, Bion, Gen-X, FX Multilayer, DRS, HT+ Preshades). The company also supplies titanium abutment blanks and titanium bases for implant prosthetics, supported by specialized Ceramill software modules. Amann Girrbach maintains a global service network across over 90 countries, providing 24/7 technical support via the Ceramill Helpdesk, on-site service, and comprehensive training through the AG.Academy. The company serves dental laboratories, private dental practices, and clinics globally, with regional hubs in Austria (headquarters in Mäder), Germany, North America, Italy, France, Singapore, Brazil, and China.

i3 Membrane GmbH develops advanced separation technologies and infection prevention solutions for medical, laboratory, pharmaceutical, and biotechnology applications. The company specializes in metal-coated track-etched polymer membranes and porous foils for filtration, adsorption, and chromatographic purification. In the medical segment, i3 Membrane manufactures point-of-use and inline water filtration systems including the i3 ONE (tap water filter), i3 TWO (shower filter), i3 FOUR (dental and ENT applications), and i3 FIVE (endoscopy). These systems address hospital water hygiene and infection prevention requirements. The laboratory and pharmaceutical division offers PET and PC membranes with gold or aluminum coatings for particle analysis, microplastic detection, and asbestos analysis, along with air monitor cassettes and vacuum filtration units. The biotech segment provides membrane adsorber technology for therapeutic product purification and a Smart Control Unit for process digitalization. Products feature enhanced conductivity and inertness properties enabling applications from sterile filtration to membrane chromatography. The company emphasizes digital separation techniques and regulatory-compliant solutions for healthcare and research environments. Manufacturing capabilities include coated polymer membrane production and modular filtration system assembly.

Sculpture Studios is a digital dentistry and CAD/CAM manufacturing services provider serving dental practitioners and laboratories. The company specializes in digital dental solutions, offering design, milling, and manufacturing services for dental restorations and prosthetics. Their service portfolio includes digital imaging analysis, CAD/CAM design and fabrication, and related manufacturing capabilities for the dental industry. Sculpture Studios supports dental practices and laboratories seeking to integrate digital workflows into their operations, enabling efficient production of custom dental appliances and restorations.

Spencer Health Solutions is a digital health company specializing in intelligent medication management systems. The company develops and markets the spencer® smart medication dispenser—a user-friendly automated dispensing device designed to improve medication adherence across clinical trials, patient support programs, care management, nursing homes, and home care settings. The spencer platform combines hardware (smart dispenser) with a data-driven software ecosystem that delivers real-time adherence monitoring, predictive analytics, visual reminders, and survey capabilities. Spencer's core value proposition addresses the WHO-documented 50% non-adherence rate among chronic disease patients by automating dose timing, providing audio and visual cues, and eliminating manual medication management errors. The company serves pharmaceutical companies (clinical trial sponsors and patient support program directors), healthcare providers, nursing facilities, and home care agencies. Spencer has dispensed over 6.2 million medication doses across 1,367 unique pill types and has operated for 5+ years. The platform generates actionable insights on medication patterns, dosing compliance, and patient engagement metrics to support clinical decision-making and care optimization. No FDA 510(k), ISO, or CE certifications are explicitly mentioned on the site.

HealthBeacon develops FDA-cleared smart injection care management systems (ICMS) that track medication adherence for patients using injectable therapies. The company's flagship product, the Smart Sharps Bin, is an intelligent sharps disposal device that sends injection reminders via blue lights and text notifications, automatically records medication drops, and integrates with a companion mobile app for patient tracking and caregiver sharing. The system captures behavior-based adherence data to support patients in staying on schedule and provide healthcare professionals and specialty pharmacies with actionable insights. HealthBeacon operates globally (15+ countries) with headquarters in Dublin, Ireland, serving patients, healthcare professionals, specialty pharmacies, and pharmaceutical companies. Clinical evidence demonstrates up to 26% improvement in medication adherence and 19% improvement in persistence at 12 months. The platform includes a Care Team available for patient interventions and remote therapeutic monitoring (RTM) code integration for Medicare/Medicaid coverage in the US. The company emphasizes sustainability through injection waste reuse and recycling via its HB Green Labs facility, offering prepaid mailback services in the US and Ireland. HealthBeacon holds FDA clearance, ISO 13485 certification, CE marking, HSE approval, NHS accreditation, HIPAA compliance, and regulatory approval across multiple jurisdictions.

NinoMed is a medical device and business analytics company specializing in innovative surgical positioning and patient safety solutions. The company manufactures Safe-T-Secure®, an all-in-one Trendelenburg positioning system for robotic and laparoscopic surgery that stabilizes patients during operative procedures. Pluma-Soft® is a pressure distribution system featuring double-layered convoluted foam overlays designed to prevent pressure ulcer formation on operating room tables during prolonged surgical procedures. Additional product lines include STS-BodyPad™ positioning kits in various configurations, Pluma-Soft Head-To-Toe™ OR table pads, PneumoHub™ for CO2 insufflation and scope cleaning control, and Cush-In It™ IV wrap for protecting patient tubing and accessories during surgery. Beyond medical devices, NinoMed offers Safe-T-Net™, a business analytics and revenue cycle management solution that helps healthcare facilities identify and recover billing opportunities. The company serves hospitals and surgical centers seeking to improve operational efficiency, patient safety outcomes, and financial performance.

Joerns Healthcare is a vertically-integrated designer, developer, and manufacturer of post-acute care equipment and solutions serving long-term care, assisted living, skilled nursing, and homecare settings. The company specializes in fall management, advanced wound care, patient handling and mobility, and integrated care solutions. Core product categories include hospital beds (including low-profile fall-risk reduction models), therapy surfaces (featuring the proprietary Dolphin® Fluid Immersion Simulation® system), patient lift systems, transfer aids, and specialized mobility devices. Joerns operates as a full-service provider with clinical evidence supporting product efficacy: their low-bed design reduces fall risk by 36%, and their fluid immersion therapy system is clinically equivalent to air-fluidized systems per Northwestern University research. The company also offers connected care and health technology solutions including Joerns Connexio®, a chronic care management platform; an asset management system for real-time equipment tracking and optimization; and digital wound imaging technology for bacterial load detection. Services include AssetCare™ asset management programs, training and education for healthcare professionals, and customer support. With over a century of operational history and five decades of innovation leadership, Joerns targets administrators, healthcare facility operators, and individual homecare users. The company emphasizes clinical outcomes, operational efficiency, and financial value through standardized, configurable product portfolios designed to reduce total cost of ownership and support evidence-based care delivery across post-acute settings.

Attindas Hygiene Partners is a leading global personal care products manufacturer specializing in adult incontinence, baby care, and clinical hygiene products. The company operates through a portfolio of subsidiary brands and direct-to-consumer channels, serving healthcare facilities (nursing homes, hospitals), pharmacies, retailers, and online channels worldwide. Core product lines include absorbent hygiene products for adult incontinence care and pediatric/baby care applications. The company has developed Attincare, a proprietary internet-based software platform designed to help nursing homes optimize organization, planning, and cost control. Attindas serves institutional healthcare markets (hospitals, skilled nursing facilities), retail pharmacy and consumer distribution, and operates a direct-to-consumer adult incontinence business in North America. The company emphasizes innovation in absorbent technology, user needs assessment, and product development informed by caregiver and healthcare professional input. Manufacturing and distribution capabilities span multiple global regions with localized market expertise.

CellaVision AB is a global leader in digital hematology microscopy solutions with over 30 years of experience. Headquartered in Lund, Sweden, the company operates in 13 regional markets with presence in over 40 countries and has sold more than 9,500 units worldwide. CellaVision provides integrated digital cell morphology systems including analyzers, instruments, reagents, software, and training solutions for hematology laboratories. The product suite covers analysis of human and animal blood and body fluid samples, including bone marrow aspirate applications. CellaVision Software 7.2 represents their latest digital cell morphology platform, designed to automate laboratory workflows, minimize human error, and enhance cross-site collaboration. Manufacturing of analyzers is outsourced in Sweden while stain reagents are manufactured in-house in Bordeaux, France. The company employs 250 staff globally and serves reference, hospital, and diagnostic laboratories. Products support routine hematology analysis, proficiency testing, training, and education. Regulatory compliance and quality standards are integral to their offerings, as evidenced by customer adoption across major healthcare networks in Canada, India, Sweden, and the United States.

Thermo Fisher Scientific is a global leader in life sciences and laboratory equipment, consumables, and digital solutions. The company manufactures and distributes a comprehensive portfolio of products for research, diagnostics, and bioprocessing applications across academic, pharmaceutical, biotechnology, and clinical laboratory markets. Product lines include transmission electron microscopes (Glacios 3 Cryo-TEM for structural biology), cell culture media and supplements (Gibco brand), molecular biology reagents (TaqMan and SuperScript PCR systems), transfection reagents (Lipofectamine), assay kits, fetal bovine serum, laboratory consumables (tubes, plates, magnetic beads), and analytical instruments. The company serves drug discovery, genomics, proteomics, cell culture, viral production, and materials analysis workflows. Thermo Fisher operates a robust e-commerce platform with online ordering of thousands of SKUs, technical support resources, interactive media selection tools, and educational content. The organization maintains ISO certifications and FDA compliance for its clinical and diagnostic products, with manufacturing facilities and distribution networks across North America and globally.

Compression Solutions provides post-surgical recovery solutions for outpatient surgery centers, hospitals, and ASCs. The company specializes in DVT (deep vein thrombosis) prevention through mechanical compression therapy wraps and cold compression devices, eliminating the need for pharmaceutical interventions. Core offerings include the Triple Play Pro™ and Triple Play VT® compression systems, PlasmaFlow DVT Prevention devices, and the AmbIT opioid-free pain pump for at-home pain management. Additionally, Compression Solutions offers ScanChart surgical notes software and comprehensive medical billing services to streamline administrative workflows and reduce paperwork burden for clinical staff. The company provides 24/7 US-based customer support for device troubleshooting and patient education, positioning itself as an integrated partner for surgery center operational efficiency and patient post-operative care optimization.

CandidPro is a doctor-directed clear aligner orthodontic platform operated by Candid Care Co. Launched in 2022, the platform provides dental professionals with integrated treatment planning software, custom clear aligners, and patient monitoring tools. The system features CandidMonitoring™, an app-based at-home progress tracking system enabling virtual oversight every 1–2 weeks. CandidPro delivers full aligner sets customized to individual patient needs, adjustable every 1–2 weeks, plus premium whitening foam and retainer products. The platform integrates with existing dental software workflows and emphasizes a doctor-directed approach to orthodontic care, targeting common bite misalignments and supporting long-term oral-systemic health outcomes. Supported by a network of dentists and orthodontists, CandidPro combines advanced appliance manufacturing with digital tools to enhance treatment efficiency and patient compliance.

VisionHealth GmbH is a German digital health company specializing in innovative, patient-centric solutions for optimizing inhaled medication delivery. The company develops the Kata® app, a CE-marked medical device that uses artificial intelligence to provide real-time feedback and guidance on proper inhaler technique. The app addresses a critical clinical problem: improper inhaler use, which affects nearly all patients and leads to increased asthma exacerbations, hospitalizations, and poor therapeutic outcomes. Kata® features step-by-step inhalation instructions with real-time feedback on breathing technique and device handling, a digital therapy plan with reminders, and patient wellness tracking. The application is one of the first AI-driven digital health solutions to achieve CE marking across Europe. VisionHealth combines expertise in healthcare and digital technologies to improve clinical outcomes and patient quality of life for those with respiratory diseases. The company serves hospital systems, healthcare providers, and patients requiring optimized respiratory therapy management.

Gilero is a contract development and manufacturing organization (CDMO) specializing in the design, development, and manufacturing of medical devices and drug delivery systems. Founded in 2002 and headquartered in Durham, North Carolina, Gilero became part of the Sanner Group in September 2024, expanding its global capabilities. The company offers comprehensive end-to-end services across the entire product lifecycle, including design and engineering, concept development, prototyping, clinical and small-batch manufacturing, electromechanical systems integration, human factors and usability engineering, regulatory affairs support, and full-scale contract manufacturing. Gilero operates over 300,000 square feet of ISO-certified cleanroom manufacturing facilities (ISO Class 7 and 8) across North America, Europe, and Asia, enabling both small-batch and high-volume production. With more than 130 engineers and regulatory experts, Gilero supports device development from initial concept through commercialization, serving diverse therapeutic areas including closed-system drug transfer devices, surgical instruments, ocular implant delivery systems, and hemostasis devices. The company combines expertise in biomedical, mechanical, electrical, and software engineering to deliver scalable manufacturing solutions tailored to client specifications and regulatory requirements.