Neurology in North Carolina

React Innovations manufactures the REACT system, a non-invasive neuromuscular stimulation device based on Extracorporeal Magnetic Innervation (ExMI) technology. The system uses gradient magnetic pulses to penetrate muscle tissue up to 4 inches deep, inducing contractions without needles, skin contact, or patient disrobing. Core applications include pain management (opioid-free), strength building post-injury, disuse atrophy recovery, range-of-motion restoration, senior fall-prevention programs, and neuromuscular re-education following traumatic injury or surgery. The REACT table features a built-in magnetic head, power coils, cooling systems, and a 450 lb capacity athletic treatment surface. Treatments typically last 20–30 minutes and are billable under CPT codes 97032 and 97112. The technology is supported by 20+ years of research published in peer-reviewed journals and cited in 2,700+ Google Scholar references. React distributes through a network of certified provider clinics (chiropractic, physical therapy, athletic training, university, and professional sports facilities) across North America. Operator certification is mandatory prior to patient treatment. The company markets to acute care, rehabilitation, long-term care, consumer wellness, and competitive athletics segments.

Shenzhen Konmed Technology manufactures biofeedback nerve and muscle stimulation devices for neurological rehabilitation and home care applications. The company's core product lines include biofeedback stimulators (KM270, KM270 Pro, KM560, KM580) and functional electrical stimulation (FES) systems for motor recovery, pain management, and pelvic floor rehabilitation. Recent product expansions include pulsed electromagnetic field therapy (PEMF) and low-intensity focused ultrasound (LIFU) wearable solutions. Konmed's devices target post-stroke rehabilitation, spinal cord injury recovery, peripheral nerve injury, chronic pain management, and pelvic floor dysfunction. The company holds MDSAP certification (Medical Device Single Audit Process) and FDA clearance, demonstrating compliance with US, Canadian, Japanese, and Australian regulatory standards. Manufacturing and R&D operations are based in Shenzhen, China. Products are marketed internationally through distributor networks in Europe, India, and other regions. The company emphasizes clinical efficacy through biofeedback integration and graduated therapeutic protocols.

Zeto, Inc. manufactures rapid, gel-free, portable EEG headset systems for point-of-care neurological diagnostics. The company's primary product line includes Zeto ONE, a full-montage EEG system for ICU, emergency departments, and EMS transport, and Zeto New Wave™, a streamlined outpatient EEG solution for clinics. Both systems feature wireless, battery-powered operation with no skin preparation required and soft-tip electrodes that leave no residue. Zeto's platform includes a HIPAA-compliant cloud-based software suite with real-time remote video viewing, collaborative review tools, and an integrated report generator. The company offers optional EEG reading services performed by board-certified neurologists. Zeto has also launched NeuroPulse™, an AI-powered software tool for seizure burden and status epilepticus detection using full 10-20 montage EEG in collaboration with encevis. The system is designed to reduce operator training burden by enabling non-specialist staff to perform acquisition while maintaining diagnostic-quality full-montage recordings. Zeto's customer base includes 200+ healthcare facilities, hospitals, neuroscience research labs, clinical trials sites, and neurofeedback centers. The company supports multiple research initiatives through collaborations with universities including Vanderbilt, University of North Carolina, UT Austin, and Baylor University. Primary market segments include acute care (ICU, emergency), outpatient neurology clinics, research institutions, and underserved healthcare settings seeking rapid EEG access.

Saebo, Inc. is a Charlotte, North Carolina-based medical device manufacturer specializing in evidence-based rehabilitation solutions for stroke survivors and individuals with neurological injuries. Founded in 2001 by occupational therapists, Saebo develops innovative products for upper and lower limb recovery, hand function restoration, and pain management. The company's portfolio includes exoskeleton devices, dynamic hand splints, electrical stimulation systems, and foot drop braces designed for both clinical and home use. With a global presence across six continents and support for over 100,000 individuals, Saebo combines clinical expertise with affordable, research-backed therapeutic solutions. The company emphasizes evidence-based practice and serves hospitals, rehabilitation clinics, therapists, and direct consumers, including a dedicated focus on veteran populations.

Kiso ehf develops and markets KineMotion, a wireless surface electromyography (sEMG) system for rehabilitation, physical therapy, sports science, and athletic training. The KineMotion platform consists of wireless sensors placed on muscles to measure and visualize real-time muscle activation patterns, coupled with tablet-based software for assessment and tracking. The system enables clinicians and trainers to detect muscle imbalances, provide live biofeedback during exercise, monitor rehabilitation progress objectively, and make evidence-based return-to-activity decisions. Key features include portable design, minimal setup time, guided measurement protocols, EMR integration, and longitudinal progress tracking. Primary markets include physical therapists, sports medicine clinicians, athletic trainers, research institutions, and professional/amateur athletes. The company has demonstrated clinical validation through endorsements by rehabilitation specialists and partnerships with professional sports teams. KineMotion protocols address common injury sites including hamstrings, ACL, calf, and shoulder. The system supports quantitative assessment where traditional manual observation may miss subtle muscle imbalances, reducing re-injury risk.

Aleva Neurotherapeutics SA is a Swiss medical device company specializing in Directional Deep Brain Stimulation (DBS) systems for treatment of neurological and psychiatric disorders. The company was founded as a spin-off from the Swiss Federal Institute of Technology in Lausanne and manufactures the directSTIM™ DBS system, featuring a proprietary 24-contact directional lead with Multiple Independent Current Control (MICC) generator technology. The system enables physicians to deliver highly precise directional stimulation, improving therapeutic benefits while minimizing side effects and reducing non-responder patient rates and revision procedures. Aleva holds 13 patent families and 90 granted patents in DBS technology. The directSTIM™ system has obtained CE marking for European distribution and MRI approval. Manufacturing and headquarters are located in Lausanne, Switzerland, leveraging the country's precision manufacturing expertise. The company targets neurologists and neurosurgeons in Europe and aims to expand to additional worldwide markets. Aleva positions itself as a specialized, responsive partner focused on addressing the clinical challenges faced by healthcare professionals treating Parkinson's disease and other neurological conditions requiring neuromodulation therapy.

Mavidon Medical Products is an FDA-registered manufacturer and packager of liquid medical products based in Flat Rock, North Carolina. The company specializes in medical adhesives, adhesive removers, natural cleaners (MaviGreen™ line), skin preparation products, and specialty medical solutions including collodions for EEG electrode attachment and medical skin prep applications. Core capabilities include contract manufacturing and private labeling with flexible filling options—cup filling, tube filling, bottle filling, and form-fill-seal operations—accommodating volumes from 9 grams to drums. Product portfolio encompasses liquids, gels, lotions, and flammable/non-flammable formulations. Twenty percent of business is dedicated to contract packaging and co-packing services with low quantity minimums, serving neurology, medical device, and specialty markets.