Ophthalmology in North Carolina

StaClear, Inc. manufactures specialized low-particulate single-use intravitreal syringes designed for ophthalmic drug delivery. The company's flagship product line addresses a critical clinical need: reducing silicone oil contamination in intraocular injections, a problem previously associated with floaters and elevated intraocular pressure when generic insulin syringes were used for intravitreal drug administration. StaClear offers three syringe configurations, all in 0.25 mL volume: - Attached Needle (SC250AN): pre-assembled with needle, ready-to-use - Luer Slip (SC250LS): compatible with standard ophthalmic needles via slip connection - Luer Lock (SC250LL): secure needle attachment via luer lock mechanism, available in both tray packs and unit packs The syringes feature a patented immobilized silicone coating anchored to syringe walls rather than liquid silicone oil, meeting USP <789> standards for low particulate matter. Engineered specifically for retina specialists, the design minimizes dead space to reduce drug wastage (saving up to $10–15 per injection), ensures precise dosing accuracy, and maintains elastomer piston sealing integrity. StaClear's SC250AN received FDA 510(k) clearance. All products carry CE marking and meet biocompatibility and chemical standards for ophthalmic use. The company was supported by NIH National Eye Institute SBIR grants during R&D and maintains strong relationships with retina practices, compounding pharmacies, outsourcing facilities, and ophthalmic pharmaceutical companies. Product guides and technical documentation available on the website.

RAUMEDIC AG is a Germany-based (Helmbrechts) manufacturer specializing in polymer-based medical devices and pharmaceutical components. The company develops and manufactures tubing systems, catheters, cannulas, syringes, and infusion sets for cardiosurgery, cell and gene therapy, drug delivery, enteral feeding, infusion therapy, neuromonitoring, ophthalmology, orthopedics, and traumatology applications. RAUMEDIC operates an in-house online shop for single-use bioprocess equipment and offers comprehensive services including material expertise, product design, prototyping, manufacturing, and regulatory support (product registration guidance). The company maintains competencies across material development, product concept design, precision prototyping, and multiple manufacturing technologies. RAUMEDIC serves hospitals, pharmaceutical manufacturers, and biotech firms globally, with demonstrated commitment to sustainability including development of low-carbon footprint medical consumables. The company is headquartered in Germany with operations indicated in multiple markets.

Leica Microsystems, a Danaher company, manufactures and sells optical and digital microscopy solutions for life science research, medical/surgical applications, industrial inspection, forensics, and education. The company serves over 175 years of heritage in revealing microscopic structures through advanced imaging technology. Product portfolio includes light microscopes (inverted and stereo), surgical microscopes for ophthalmology, neurosurgery, ENT, plastic reconstructive surgery, and dentistry. Key products include the DMi8 inverted microscope platform for research workflows, MyVeo all-in-one surgical visualization headset for heads-up OR collaboration, Ivesta 3 Greenough stereo microscopes for industrial inspection, Stellaris confocal microscopes, and Proveo 8x 3D digital surgical microscopes. The company offers sample preparation equipment including the UC Enuity ultramicrotome for electron microscopy. Aivia is their AI-powered 2-to-5D image visualization, analysis, and interpretation platform for complex image processing. ATTO-TEC consumables (fluorescent dyes) serve fluorescence microscopy imaging applications. Leica operates an online shop with pre-configured bundles and provides remote care/predictive service systems. The company maintains global distribution through authorized partners and serves clinical, research, and industrial markets. Regional presence includes Germany (headquarters in Wetzlar) with US operations.

Rasimo Systems is an FDA-listed integrated health technology company specializing in AI-driven digital therapeutics and remote patient monitoring solutions. The company develops the SureMediks® platform, a comprehensive AI-powered digital health ecosystem designed to manage metabolic risk factors including obesity, diabetes, cardiovascular disease, and MASLD. SureMediks integrates connected medical devices (blood pressure monitors, smart scales, glucose meters, ECG wearables, oximeters, CGM systems, and smart rings) with proprietary "Realistic Intelligence" AI to deliver real-time patient monitoring, personalized treatment pathways, lifestyle interventions, and clinical decision support. The platform connects seamlessly to existing EMR systems via standard APIs and includes customizable dashboards for healthcare providers. Rasimo manufactures FDA-compliant medical devices and offers end-to-end solutions including custom device design, medical software development, EMR integration, and HIPAA-compliant telehealth systems. The company also produces AI-enabled hearing aids (BTE, RIC, ITE styles) and wellness platforms (SureFiz Pro). Serves healthcare providers, pharmaceutical companies, insurers, fitness professionals, and enterprise wellness programs.

TeraRecon, Inc. is a healthcare software company specializing in AI-powered advanced medical imaging visualization and enterprise image management solutions. The company delivers SaaS-based platforms—TeraRecon AV (registered as Intuition globally) and TeraRecon DETECT—that combine advanced 3D visualization with AI-driven automation to enhance diagnostic precision and clinical workflow efficiency. Products support radiology, cardiology, neurology, vascular surgery, and oncology applications with features including medical image viewing, AI biomarker detection, real-time decision support, and enterprise imaging consolidation. Founded in 1997 and based in Durham, North Carolina, TeraRecon serves approximately 1,900 clinical sites globally with ~195-244 employees and ~$41M annual revenue. The platform emphasizes interoperability, enabling integration with existing hospital imaging systems while automating routine interpretation tasks and reducing clinician time-to-diagnosis.

Hydromer, Inc. is a global B2B provider of surface modification and coating solutions, specializing in hydrophilic polymer research, development, and manufacturing. Founded in 1980 and based in Concord, North Carolina, the company is ISO 9001:2015 certified with over 40 years of expertise in creating innovative polymer-based products for medical devices, industrial plastics, and specialized applications. Hydromer offers a comprehensive portfolio of hydrophilic coatings—including UV-curable and thermal-curable systems—tailored for cardiovascular, gastroenterology, neurovascular, ophthalmology, peripheral vascular, and urological devices. The company provides end-to-end services including custom formulation development, contract coating, R&D services, FDA regulatory support, and technology transfer. With a 98% repeat customer rate and support for over 1,000 medical device customers worldwide, Hydromer delivers lubricious, anti-thrombogenic, and performance-enhanced coatings for catheters, guidewires, balloons, stents, endoscopes, and other interventional and diagnostic devices. Global production and service hubs ensure consistent quality and responsive support across Asia and the Americas.

Gilero is a contract development and manufacturing organization (CDMO) specializing in the design, development, and manufacturing of medical devices and drug delivery systems. Founded in 2002 and headquartered in Durham, North Carolina, Gilero became part of the Sanner Group in September 2024, expanding its global capabilities. The company offers comprehensive end-to-end services across the entire product lifecycle, including design and engineering, concept development, prototyping, clinical and small-batch manufacturing, electromechanical systems integration, human factors and usability engineering, regulatory affairs support, and full-scale contract manufacturing. Gilero operates over 300,000 square feet of ISO-certified cleanroom manufacturing facilities (ISO Class 7 and 8) across North America, Europe, and Asia, enabling both small-batch and high-volume production. With more than 130 engineers and regulatory experts, Gilero supports device development from initial concept through commercialization, serving diverse therapeutic areas including closed-system drug transfer devices, surgical instruments, ocular implant delivery systems, and hemostasis devices. The company combines expertise in biomedical, mechanical, electrical, and software engineering to deliver scalable manufacturing solutions tailored to client specifications and regulatory requirements.