Orthopedics in Colorado

GID Bio is a clinical-stage regenerative medicine company developing autologous stromal vascular fraction (SVF) cell therapy for osteoarthritis treatment. The company has completed a Phase 3 FDA IDE clinical trial for knee osteoarthritis, demonstrating 73% reduction in pain and 115% improvement in function versus sham control with no adverse safety events reported. GID Bio is preparing a PMA (Premarket Approval) submission to the FDA. The therapy uses the patient's own cells (autologous approach) rather than allogeneic stem cells, positioning it within the cell therapy and regenerative medicine space. Leadership includes founders with orthopedic and plastic surgery expertise (Adam Katz, MD; J. William Futrell, MD; G. Patrick Maxwell, MD; Ramón Llull, MD, PhD) and experienced board members. The company is pre-commercial, currently advancing through the FDA approval pathway with intent to commercialize following regulatory clearance.

3D Systems is a leading provider of additive manufacturing (3D printing) solutions for industrial and healthcare applications. The company manufactures a comprehensive portfolio of commercial 3D printers capable of producing plastic, metal, elastomer, composite, wax, and biocompatible parts at point-of-need, significantly reducing production timelines compared to traditional subtractive manufacturing. Core product lines include direct metal printing systems, plastic-based printing platforms, and specialized materials for aerospace, automotive, dental, medical device, and semiconductor industries. 3D Systems also develops AI-powered software for design-to-production workflows and provides application innovation consulting services. In healthcare, the company serves dental labs, orthopedic manufacturers, and biomedical researchers; notable medical applications include custom dental solutions (NextDent jetted denture systems with EU MDR certification), patient-specific surgical guides, and bioprinted tissue scaffolds. The company maintains certifications for medical device manufacturing and serves enterprises including Airbus, Lucid, Jabil, and academic institutions (MIT, Imperial College, ETH Zurich). Manufacturing capabilities span both hardware production and materials development, with a global service and support network.

Mighty Oak Medical is a commercial-stage medical device development company specializing in patient-specific solutions for complex spinal surgery. Founded in 2011 and based in Englewood, Colorado, the company designs and manufactures advanced surgical planning, guidance, and visualization tools that enhance safety, precision, and efficiency in spine instrumentation procedures. The company's core competencies include AI-driven 3D pre-surgical planning, 3D-printed patient-specific surgical navigation guides, and anatomical bone models. The flagship FIREFLY Pedicle Screw Navigation Guides platform is FDA-cleared and CE-marked, providing surgeons with personalized pre-operative planning, intraoperative guidance, and detailed anatomical analytics to reduce operative time, improve screw placement accuracy, and lower radiation exposure during cervical, thoracolumbar, and pelvic instrumentation. Mighty Oak partners with HP for advanced 3D manufacturing using Multi Jet Fusion technology and with OrthoPediatrics for exclusive distribution in children's hospitals. The company has completed 3,700+ cases, planned 80,000+ screws, earned 9 FDA clearances, and holds 100+ patents worldwide.

Intellijoint Surgical is a Canadian medical technology company that develops and commercializes surgical navigation solutions for total joint replacements, including hip and knee arthroplasty. The company provides both pre-operative planning software and intraoperative navigation systems designed to improve surgical accuracy, reduce outliers, and enhance patient outcomes. Intellijoint VIEW is a web-based surgical planning platform that enables functional cup planning, implant templating, and coronal alignment planning without requiring CT imaging, with support for mechanical, kinematic, and restricted kinematic alignment targets. Intellijoint HIP delivers real-time intraoperative implant measurements for primary and revision total hip arthroplasty procedures. Intellijoint KNEE provides intraoperative measurement capabilities, instrumentation alignment guidance, and bony cut positioning assistance for knee replacement implantation. The solutions target orthopaedic surgeons, surgical care teams, and healthcare administrators seeking affordable, user-friendly navigation technology that reduces complexity and cost compared to traditional systems. The company serves the US and Canadian markets and has established strategic partnerships to expand orthopaedic procedural capabilities. Products are designed for ease of use and accessibility across varying surgical facility types and surgeon experience levels.

Exer Labs develops an FDA-registered Class II medical device software platform that delivers AI-powered motion analysis and clinical decision support for musculoskeletal and movement disorders. The platform captures objective movement data via smartphone or tablet cameras (no wearables required) in clinic and home settings, applying proprietary neural networks to generate real-time insights on gait, joint mobility, hand/wrist function, and functional movement patterns. The system is HIPAA-compliant and integrates with existing EHR workflows via barcode scanning and APIs. Primary clinical applications include orthopedics (major joints, hand, wrist), neurology (Parkinson's, digital movement evaluation), physical medicine and rehabilitation (personalized treatment planning), senior living (fall risk detection and prevention), and primary care (early intervention and objective outcome tracking). The platform features in-clinic capture apps, at-home patient monitoring via mobile app, real-time clinician dashboards, automated billing reports, and standardized outcome measures. Exer's AI is wholly proprietary and internally trained. Clinical validation includes collaborations with Mayo Clinic (hand and wrist disorders), Wake Orthopedics, and Legacy Healthcare (senior living), with demonstrated accuracy compared to traditional goniometry. The solution addresses provider workflow integration, remote monitoring capabilities, and cost optimization through reduction of unnecessary diagnostic testing and improved care coordination across inpatient, outpatient, and home-based care settings.

Aclarion, Inc. is a healthcare technology company specializing in noninvasive diagnostic software for chronic low back and neck pain management. The company develops the NOCISCAN platform, a SaaS solution that leverages magnetic resonance spectroscopy (MRS) to analyze pain biomarkers in lumbar discs and distinguish between painful and nonpainful vertebral segments. NOCISCAN complements conventional lumbar MRI imaging by providing objective, patient-specific pain biomarker data without requiring invasive provocative discography. The platform generates individualized NOCI+/NOCI- scores for each disc, enabling clinicians to personalize treatment and surgical planning. NOCISCAN integrates with existing high-field MRI systems and includes components such as the MRS Exam Protocol, AMBRA Healthcare integration, and NOCIWEB data transfer capabilities. The solution supports improved surgical outcomes by helping physicians identify the true source of discogenic pain and optimize candidate selection for interventional procedures including fusion and disc replacement.

Sontec Instruments, Inc. is a family-owned medical surgical instrument distributor and supplier based in Centennial, Colorado, serving the healthcare market for over 50 years. The company specializes in providing high-quality surgical instrumentation across all surgical specialties, including cardiovascular/thoracic, urological, orthopedic, arthroscopic, ENT, colorectal, ophthalmic, plastic surgery, dermatologic, neurosurgical, and microsurgical applications. Product lines include specialty instrument sets with trays, forceps (Backhaus towel forceps, Crile forceps in standard and Quantum grades), knife handles with calibrated grip options, retractors, and arthroscopic/endoscopic system components. Notable offerings include spine surgery instrument sets (lumbar, minimally invasive, extended split tube configurations), penile implant and sphincter surgery sets, and veterinary arthroscopy equipment. The company maintains an online B2B ordering platform restricted to registered and approved customers, with clearance product inventory available. Sontec emphasizes personalized service, first-rate packaging, and compliance with surgical instrument industry standards. The organization is supported by partnerships with Colorado State University veterinary medicine programs and international surgical instrument manufacturers including Dufner Tuttlingen.

Neuralytix develops proprietary mechanomyography (MMG) technology for intraoperative nerve assessment during spinal surgery. The FDA-cleared iD3 System provides surgeons with real-time, objective measurements of nerve function through non-invasive accelerometer sensors, replacing subjective tactile feedback and invasive EMG. The system assists in nerve locating, mapping, and decompression assessment across minimally invasive and open spinal procedures, including fusion, discectomy, laminectomy, and foraminotomy. MMG enables surgeons to quantify neural response threshold changes throughout surgery, improving decision-making precision and reducing reoperation risk while eliminating procedural complexity associated with traditional EMG monitoring.

Mitaka USA, Inc. is a medical technology manufacturer founded in 1997, specializing in advanced optical, electronic, fluorescence, microscopic, and 3D imaging devices for microsurgery. Headquartered in Wheat Ridge, Colorado, the company develops high-precision surgical visualization and instrumentation tools targeting ENT, neurosurgery, plastic surgery, hand surgery, spine, and wound care specialties. The product portfolio includes the MM77, MM90, MM80 SS1, and MM51 microscopy systems featuring integrated fluorescence imaging and ICG (indocyanine green) detection for real-time tissue visualization during minimally invasive procedures. Complementary offerings include the UniARM surgical arm positioning system, EMI Instruments (Supermicro microsurgical instruments), HawkSight imaging enhancement, Crownjun Suture materials, and Pero-System limb volume measurement technology. Mitaka also provides WetLab training vessels and comprehensive surgeon training programs to support professional development across multiple surgical disciplines. The company emphasizes agile product development, responsive customer service, and precision engineering to enhance surgical performance and patient outcomes.

SpineGuard SA is a French medical device company specializing in surgical guidance technology for spine surgery. The company manufactures PediGuard® devices equipped with DSG® (Dynamic Surgical Guidance) Technology, handheld drilling instruments designed to alert surgeons in real time of potential vertebral cortical wall breaches during pedicle screw placement and other spinal procedures. The PediGuard line includes the PediGuard Threaded device, specifically engineered for anterior approach spine surgery with controlled trajectory insertion. DSG Technology provides 100% medial pedicle breach anticipation, real-time feedback at the instrument tip, reduced intraoperative radiographic exposure, and improved placement accuracy for pedicle screws. The technology uses electrical conductivity principles to detect proximity to critical neural and vascular structures. SpineGuard operates globally with headquarters in Vincennes, France, and a US subsidiary in Boulder, Colorado. The company serves orthopedic spine surgeons, neurosurgeons, and surgical centers performing minimally invasive and open spine procedures. Products are designed for both thoracoscopic and traditional open surgical approaches. The company emphasizes safer implant placement, reduced radiation exposure, and streamlined surgical workflow. Clinical support from renowned spine surgeons validates the technology's efficacy in breach anticipation and placement accuracy.

David Health Solutions manufactures data-driven, device-based exercise therapy equipment for musculoskeletal rehabilitation, specializing in spine, shoulder, hip, and knee conditions. The company offers electromechanical rehabilitation devices classified as Medical Class 1m under Directive 93/42/EEC, engineered and manufactured in Finland since the 1980s. DAVID's product portfolio includes specialized exercise machines designed to prevent harmful movements while providing high muscular fatigue with joint safety, individually tunable for patient-specific needs. The company's integrated offering combines hardware with EVE, a comprehensive SaaS software platform available in 20+ languages. EVE features intake automation, mobility and isometric testing, therapy documentation, AI-driven training program automation, home exercise programs, appointment scheduling, and HL7/API integration with EMR systems. The EVE mobile app enables patient engagement with home exercise tracking, therapist communication, appointment management, and results visualization. DAVID operates a global distribution network with 600+ installations across Europe, North America, South America, Australia, and Asia, serving physiotherapy centers, chiropractor practices, hospital rehabilitation departments, orthopedic and spine centers, fitness facilities, corporate wellness programs, and military installations. The company supports customer success through the DAVID Academy, an e-learning platform offering multilingual certification courses for instructors, clinic managers, and healthcare professionals on device setup, functional testing, movement mechanics, contraindications, and EVE software optimization. Markets served include rehabilitation medicine, sports medicine, occupational health, and preventive care. DAVID's approach emphasizes evidence-based outcomes, administrative efficiency for therapists, and sustainable business models for treatment facilities.