PCR Machines in California

ResearchDx is a comprehensive diagnostic development and contract research organization (CRO) specializing in in vitro diagnostic (IVD) test development, validation, and commercialization. The company operates three integrated divisions: Contract Services (biomarker discovery, assay development, regulatory filings); Diagnostic Laboratory (CLIA/CAP/ISO 15189 accredited clinical testing under the PacificDx brand); and Diagnostic Manufacturing (ISO 13485:2016 and GMP-compliant kit manufacturing under the CustomDx brand). Core capabilities include custom molecular assay development (PCR, qPCR, ddPCR, NGS, microRNA, protein, flow cytometry, ELISA), analytical and clinical validation, companion diagnostic development, and complete laboratory accreditation consulting. The company is ISO 13485:2016 certified, CLIA approved, CAP accredited, and FDA registered. Recent achievements include FDA 510(k) clearances for GlutenID celiac genetic health risk test and regulatory approvals for companion diagnostics (ProMarkerD for diabetic kidney disease, FibroSIGHT for MASH liver fibrosis detection). ResearchDx serves pharmaceutical companies, diagnostic startups, and established laboratories requiring integrated IVD development from concept through commercialization and contract manufacturing.

Beckman Coulter Diagnostics is a global leader in clinical diagnostics and biomedical testing, headquartered in Brea, California. A subsidiary of Danaher Corporation since its foundational 1935 establishment, the company develops, manufactures, and distributes innovative laboratory automation systems, analyzers, and informatics solutions for clinical and research laboratories worldwide. The company specializes in clinical chemistry systems, immunoassay instruments, hematology analyzers, urinalysis systems, microbiology solutions, blood banking instruments, and protein chemistry platforms. Beckman Coulter also provides total lab automation systems (DxA 5000 series), advanced informatics middleware (Remisol Advance), and remote diagnostic services. Its comprehensive portfolio supports healthcare professionals and laboratory teams in disease diagnosis, treatment decisions, patient monitoring, and improved health outcomes. With annual revenue of approximately $2.9 billion, the company emphasizes efficiency, automation, clinical confidence, and integrated workflow solutions for hospital laboratories, reference laboratories, and blood banks globally.

Since 1986, Jant Pharmacal Corporation has been a leading B2B supplier of point-of-care (POC) diagnostic tests and laboratory instrumentation to U.S. and international healthcare settings. The company operates two primary divisions: POC Division and Lab Division. The POC Division offers CLIA-waived rapid tests and analyzers for use in physicians' offices, clinics, urgent care centers, and hospitals under registered trademarks Accutest, Accustrip, and LipidPlus. Product categories include cardiac testing, colorectal cancer screening, drugs of abuse, hypothyroidism, infectious diseases, pregnancy & fertility, and urinalysis. The Lab Division provides integrated solutions for laboratory optimization, featuring clinical chemistry, hematology, immunoassay, toxicology, urinalysis, and molecular diagnostic systems with reagents and consumables. The company holds GPO supplier contracts with Vizient and Champs, representing over 500,000 members. Additionally, Jant offers laboratory consultation services including financial feasibility assessment, turn-key laboratory setup, CLIA compliance consultation, LCMS method development, and laboratory information system integration.

Biobase Biodustry (Shandong) Co., Ltd is a high-tech manufacturer founded in 1999, headquartered in Jinan, Shandong, China. The company operates 25 manufacturing facilities and provides comprehensive one-stop solutions for laboratory, medical, and clinical applications. Core product categories include biological safety cabinets, laminar flow cabinets, fume hoods, sterilization equipment (autoclaves, sterilizers), clinical and analytical instruments (auto chemistry analyzers, electrolyte analyzers, blood bank refrigerators), flow cytometers, PCR cabinets, laboratory cryogenic refrigeration units, and hospital furniture (beds, wheelchairs). Biobase serves research institutions, clinical laboratories, diagnostic facilities, and healthcare providers across more than 190 countries. The company maintains in-house R&D (100+ employees), sales (200+ employees), and after-sales support teams (11+ employees). Certifications include ISO 9001, ISO 13485, ISO 14001, CE, FDA, NSF, SGS, and EN standards, reflecting compliance with international quality and medical device regulations. Services include 24-hour online customer support and warranty coverage for defective components.

Genesee Scientific LLC is a US-based distributor of laboratory equipment, consumables, and research supplies serving academic, clinical, and biotech laboratories. The company supplies a comprehensive portfolio of cell culture equipment, liquid handling systems, centrifugation equipment, sample agitation devices, and temperature control instruments from established brands including Poseidon, Benchmark, Eppendorf, Apex Bioresearch, FlyStuff, GenClone, Invictus, Next-Gen, Nutri-Fly, Olympus Plastics, and others. Product categories include cell culture equipment and cultureware, cell media, PCR reagents and consumables, nucleic acid extraction products, transfection reagents, liquid handling and pipette tips, tubes, centrifuges, incubators, drosophila-specific consumables and equipment, chemicals (acids, bases, solvents), gloves (including powder-free nitrile options), lab organization and storage solutions, and glassware. The company emphasizes reliable quality through curated product selection, exceptional cost efficiency via portfolio optimization, lab-centric solutions tailored to individual facility workflows, and support for scientific advancement. Genesee Scientific operates an e-commerce platform with account registration, personalized recommendations, promotional pricing programs, and order fulfillment. The company serves research institutions, academic labs, biotech firms, and clinical laboratories with consumables and equipment support.

Laguna Scientific is a laboratory equipment and consumables supplier specializing in molecular biology, cell culture, and sample preparation products. The company manufactures and distributes a comprehensive range of laboratory essentials including thermal cyclers (PCR equipment), shaking incubators, microcentrifuges, pipette tips in multiple volumes (10 µL, 1000 µL) with specialized formulations (RNase-free, DNase-free, endotoxin-free, PCR-inhibitor-free), microcentrifuge tubes, culture tubes with dual-position caps, multi-well cell culture plates (6-well, 12-well, 24-well, 48-well formats), and sterile cell strainers. Products are available in bulk and racked configurations to serve research institutions, clinical laboratories, biotech firms, and contract research organizations. The company emphasizes quality consumables with specifications suitable for sensitive applications such as PCR, qPCR, nucleic acid extraction, and cell culture work. Laguna Scientific operates as a direct-to-customer e-commerce supplier based in California, with capabilities to support high-volume laboratory operations.

Lusis Biosciences is a California-based leader in qPCR assays and instruments for molecular diagnostics. The company specializes in VeraPoint qPCR assays and Q-Vera instruments designed for infectious disease detection across respiratory, urinary, sexually transmitted, gastrointestinal, and bloodborne pathogen applications. Lusis develops multiplexing technology-enabled reagents that simultaneously detect multiple targets, with a catalog of over 30 key products and hundreds of additional targets. The company also manufactures nucleic acid extraction reagents and sample processing solutions. Operating in over 160 countries with 10,000+ laboratory customers, Lusis combines integrated development and manufacturing capabilities with dedicated customer support and field application scientist consultation to deliver cost-effective, accessible molecular diagnostic solutions for clinical and research laboratories.

IncellDx is a molecular diagnostics and biotechnology company specializing in single-cell diagnostics for precision medicine. The company develops and manufactures diagnostic tools, reagents, probes, and antibodies for multiplex RNA in situ hybridization and protein detection. Its proprietary SUSHI (Simultaneous Ultrasensitive Signal-amplified Hybridization In Situ) platform enables simultaneous analysis of proteomic and genomic biomarkers within intact cells without complex sample preparation. Key offerings include HPV OncoTect™ kits for cervical cancer detection, mRNA probes (HPV E6/E7, CMV), monoclonal antibodies (anti-PD-L1, anti-CD45, anti-Pan Cytokeratin), hybridization core reagents, fixatives, cell cycle assays, and the incellPREP™ tissue single-cell suspension system. Products are available in multiple regulatory statuses: RUO (Research Use Only), GPR (General Purpose Reagents), ASR (Analyte Specific Reagents), CE-IVD (European In Vitro Diagnostic), and US-IVD. The company holds FDA registration, EU IVD compliance certification, and ISO 13485 quality management certification. Clinical applications target serious viral diseases including cervical cancer, HIV/AIDS, hepatitis, COVID-19, and other malignancies.

Bio Plas, Inc. is a premier manufacturer of disposable plastic laboratory consumables serving clinical, industrial, educational, and governmental laboratory applications since 1977. Established as a Veteran Founded, Woman-Owned Small Business, the company produces a comprehensive range of FDA-compliant laboratory products including microcentrifuge tubes, pipette tips, PCR tubes, inoculation systems, and specialty histology containers. All products are manufactured in the USA under rigorous California and FDA GMP guidelines and licensed by both state and federal authorities. Bio Plas operates exclusively through a B2B distributor network, ensuring consistent quality assurance and prompt delivery to healthcare and research institutions. The company maintains BioSecure Act compliance and emphasizes premium quality combined with exceptional customer service.

EntroGen, Inc. is a molecular diagnostics company specializing in oncology and personalized medicine solutions. The company develops and manufactures FDA-approved and research-use-only (RUO) PCR-based assays for cancer biomarker detection, companion diagnostics, and minimal residual disease (MRD) monitoring. Core product portfolio includes the CRCdx® RAS Mutation Detection Kit (FDA-approved companion diagnostic for KRAS and NRAS mutations in colorectal cancer), NPM1 One-Step MRD Kit for acute myeloid leukemia detection, DPYD Genotyping Kit for pharmacogenomic assessment, and Microsatellite Instability (MSI) Detection Kit. EntroGen manufactures the Benchbot® 4800 laboratory automation platform designed to streamline workflow from sample preparation to PCR plate setup in four steps. The company offers three integrated product lines: automation equipment, molecular reagents/assays, and analysis software. All products are manufactured to ISO 13485 quality standards. EntroGen serves clinical laboratories, hospital pathology departments, and oncology centers globally, supporting treatment decision-making through molecular testing. The company participates in industry conferences including the World Clinical Biomarkers & Companion Diagnostics Summit, indicating active engagement in the molecular diagnostics and precision oncology markets.

Targeted Genomics is a family-owned molecular diagnostics company specializing in celiac disease genetic risk assessment. The company develops and offers the GlutenID™ test, an FDA-cleared at-home saliva-based genetic test that identifies HLA-DQ2 and HLA-DQ8 genotypes associated with celiac disease risk. The test is designed as a universal triage tool to distinguish at-risk individuals from those who can rule out celiac disease. Founded and led by Dr. Shelly Gunn, MD, PhD, a board-certified pathologist with expertise in molecular diagnostics and genomic analysis, Targeted Genomics partners with PacificDX, a CAP/CLIA-certified laboratory in Irvine, CA, for sample processing and analysis. The company also offers complementary celiac disease testing services including the Celiac Disease Panel (antibody testing) and CeliacDx Consult (expert pathology review). Testing workflow involves at-home saliva collection via cheek swab, mail-in sample submission with prepaid shipping, laboratory processing, and secure email delivery of results with actionable next steps. The company maintains strict privacy controls—only HLA genotypes are interrogated, genomic data is stored securely for two years per CAP requirements, and data is never sold or shared with third parties. Targeted Genomics serves consumers, families with celiac history, and healthcare providers seeking efficient genetic screening to guide subsequent antibody and biopsy testing in celiac disease diagnosis.

Twist Bioscience Corporation is a US-based synthetic biology company specializing in DNA-based research tools and services. The company operates a proprietary semiconductor-based synthetic DNA manufacturing platform utilizing high-throughput silicon technology for miniaturized chemistry and cost-efficient DNA synthesis. Core product portfolio includes synthetic genes (clonal genes, gene fragments, gene pools, vectors), oligonucleotide pools (cloned and uncloned), next-generation sequencing (NGS) target enrichment solutions, library preparation kits (including TrueAmp Library Prep Kit and PCR-free WGS kits), variant libraries (combinatorial, site saturation, spread-out low diversity), and synthetic controls for infectious disease and liquid biopsy applications. The company also offers comprehensive antibody discovery and development services including in vitro phage display, in vivo discovery using Diversimab technology and humanized transgenic mice, antibody characterization (SPR, developability assessment, functional assays), and optimization services including AI/ML-driven affinity maturation and in silico humanization. Twist Service Lab provides outsourced sequencing services, and the company offers automation solutions and API-based procurement integration. Target markets include academic research, pharmaceutical drug discovery, cancer research, infectious disease research, agricultural biotechnology, and clinical diagnostics. The platform enables researchers to access customizable gene synthesis at varying scales, perform high-confidence genomic screening, and conduct precision variant detection across NGS workflows.

DiaSorin Molecular LLC is a world leader in laboratory diagnostics, specializing in immunodiagnostics and molecular diagnostics. The company develops and manufactures in vitro diagnostic systems for detecting antibodies, antigens, and pathogens in biological specimens. Core product lines include the LIAISON® immunodiagnostic platform for infectious disease detection (tuberculosis, hepatitis, viral infections), Simplexa® molecular assay kits for direct pathogen detection (COVID-19, influenza, RSV, cytomegalovirus, herpes simplex virus), and the LIAISON NES® CLIA-waived rapid molecular test delivering results in approximately 15 minutes. Additional offerings include LIAISON® MeMed BV® for bacterial-viral differentiation, LIAISON® QuantiFERON®-TB Gold Plus II for TB detection, and LIAISON® BRAHMS PCT® for infection triage. The company also operates the Luminex division, providing xMAP® multiplex assay platforms and xMAP INTELLIFLEX® systems for research and clinical diagnostics, along with custom assay design and development services. DiaSorin serves clinical laboratories, hospitals, and research institutions globally. The company maintains regulatory compliance with FDA clearances and CLIA waivers for its diagnostic systems. Manufacturing and service capabilities span immunoassay automation, molecular PCR testing, and multiplex diagnostic platforms.

Invivoscribe is a San Diego-based molecular diagnostics company founded in 1995, specializing in precision oncology testing and personalized molecular medicine for hematologic malignancies. The company develops and manufactures CE-marked in vitro diagnostic assays, research-use-only (RUO) assays, analyte-specific reagents (ASRs), and DNA/RNA controls under ISO 13485 design control. Core product lines include next-generation sequencing (NGS) panels for clonality testing (B- and T-cell), minimal residual disease (MRD) assays (LymphTrack®, LeukoStrat® FLT3-ITD and NPM1), and companion diagnostics (CDx) for precision oncology drug therapies. Invivoscribe operates LabPMM®, a CAP-accredited clinical laboratory with multiparametric flow cytometry and molecular testing services, serving clinical laboratories, pharmaceutical companies, and researchers across 160+ countries and 700+ laboratories worldwide. The company also provides bioinformatics software, custom assay development, and turn-key CDx collaboration for pharmaceutical partners, emphasizing regulatory expertise and streamlined drug approval pathways.

Bioneer Corporation is a life-science research supplier headquartered in Oakland, CA, specializing in molecular biology reagents, enzymes, nucleic acid synthesis and preparation kits, and laboratory instruments. The company manufactures and distributes a comprehensive portfolio including DNA/RNA amplification and prep reagents (AccuPrep kits for genomic DNA, mRNA, plant genomic DNA, and universal RNA), DNA/RNA synthesis reagents and phosphoramidites, polymerases and enzymes, oligonucleotides, RNAi products (siRNA and miRNA), gene synthesis services, protein expression and purification reagents, molecular markers and ladders, plastic consumables, and specialized instruments. Bioneer also offers drug target and toxicity identification services (GPScreen) and maintains a yeast genome-wide S. pombe knock-out library for functional genomics research. The company serves academic research institutions, biotechnology firms, pharmaceutical companies, and contract research organizations in North America. Products are supported by technical protocols, material safety data sheets, reference literature, and application notes. Bioneer maintains both US operations in Oakland and international headquarters in Daejeon, South Korea. The company provides customer support via toll-free phone, email, and direct technical assistance for product troubleshooting and applications development.

ACON Laboratories, Inc. is a US FDA-registered global medical device manufacturer specializing in point-of-care testing (POCT) and immunoassay products. Headquartered in San Diego, California, the company develops and manufactures diagnostic solutions across four primary product lines: Point of Care, Immunoassays, Molecular Diagnostics, and Animal Health. Products serve hospitals, clinical laboratories, physician offices, blood banks, pharmacies, and veterinary clinics worldwide. The On Call® Blood Glucose Meter Family is designed for glucose monitoring and diabetes management. Mission® brand includes urine reagent test strips, urine analyzers, and handheld devices for cholesterol, coagulation, and hemoglobin measurement. HealthyMe® provides urinary tract infection (UTI) detection reagent strips. Flow flex® is the newest lateral flow rapid testing brand, offering multiplexed home tests including the recently FDA 510(k)-cleared Flow flex® Plus RSV + Flu A/B + COVID multiplex rapid antigen test for ages 6 months and up. The company's ACON brand offers lateral flow rapid tests for pregnancy, cancer markers, and infectious disease screening, including SARS-CoV-2 antibody and antigen tests. Distinct® provides pregnancy rapid tests using qualitative chromatographic immunoassays. Foresight® offers allergen immunoblot testing for 30 allergens on a single strip. Promotor® provides nucleic acid extraction systems and PCR quantitative test kits for HBV, HCV, HPV 16/18, HPV genotyping, tuberculosis, and HLA-B27. CentriVet® serves veterinary diagnostics with dual ketone/glucose meters and urine reagent strips. ACON maintains US FDA registration, provides contract manufacturing and OEM services, and holds multiple FDA 510(k) clearances for its diagnostic products.

Biomiga, Inc. is a San Diego-based biotech research and manufacturing company specializing in nucleic acid extraction, purification, and PCR-based diagnostic products. Core product lines include the MgPure family of automated DNA/RNA extraction kits designed for diverse sample types: pathogenic, blood, saliva, circulating cell-free DNA, and formalin-fixed paraffin-embedded (FFPE) tissue. The company manufactures DNA/RNA size-selection beads offering superior yield (10–20% better than benchmarks) at competitive pricing, with full USA manufacturing and OEM customization capability. MgPure Seq DTR beads support sequencing workflows with >800 bp average reading lengths, available in manual or automated formats compatible with major platforms (Kingfisher Flex, Biomek, Hamilton, and others). Biomiga offers comprehensive real-time PCR detection assays targeting infectious disease panels, including respiratory pathogen panels (RPP), sexually transmitted infections (STI), gastrointestinal pathogens, women's health, wound infection markers, and nail fungal detection. The company also provides customized services for gene synthesis, cell line construction, protein expression, lentivirus packaging, and next-generation sequencing. FDA-registered facility with ISO 9001:2015 certification. All extraction protocols are fully validated for automation on industry-standard platforms. The company emphasizes in-house manufacturing control, 24/7 customer support, and R&D-driven product development.

Genetic Signatures Limited is a molecular diagnostics company specializing in the development and commercialization of proprietary real-time PCR-based detection systems for infectious disease screening. The company's core platform, 3base™, utilizes streamlined sample processing methods linked to highly multiplexed real-time PCR assays to simultaneously detect multiple pathogen targets faster than conventional methods. Primary product line includes the EasyScreen™ brand of detection kits, which employ DNA methylation pattern identification and sequence simplification technology. The company has achieved FDA 510(k) clearance for the EasyScreen™ Gastrointestinal Parasite Detection Kit, now distributed through leading US clinical laboratories. Additional offerings include Analyte Specific Reagents (ASRs) for laboratory-developed test applications. Genetic Signatures serves clinical laboratories, diagnostic facilities, and healthcare systems requiring rapid, multiplexed infectious disease identification. The company maintains regulatory compliance with FDA standards and positions itself as a specialist in molecular diagnostics innovation, with particular expertise in gastrointestinal parasite and pathogen detection. Operations span both US and international markets, with documented presence in the US healthcare diagnostics sector.